Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707206 | 0.91 | EGFR (0.36) | EGFRERBB2ERBB4HTTRAF1 | |
| SCHEMBL13784501 | 0.89 | MAPK1 (0.37) | EGFRERBB2ERBB4HTTRAF1 | |
| SCHEMBL1755281 | 0.88 | NSD2 (0.39) | EGFRERBB2ERBB4HTTMAPK1 | |
| SCHEMBL1755318 | 0.87 | KDR (0.37) | EGFRERBB2ERBB4HTTRAF1 | |
| SCHEMBL1706629 | 0.81 | KDR (0.39) | EGFRERBB2ERBB4HTTRAF1 | |
| SCHEMBL1706605 | 0.80 | NSD2 (0.40) | EGFRMAPK1KDRLMNA | |
| SCHEMBL1708497 | 0.80 | NSD2 (0.49) | EGFRHTTRAF1MAPK1KDR | |
| SCHEMBL1706635 | 0.79 | LMNA (0.39) | EGFRHTTRAF1MAPK1KDR | |
| SCHEMBL1706781 | 0.79 | NSD2 (0.47) | EGFRHTTRAF1MAPK1KDR | |
| SCHEMBL1707273 | 0.79 | NSD2 (0.39) | EGFRMAPK1KDRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247579-B1 | SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS | Bayer Pharma AG (DE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2009089851-A1 | SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-23 | — | — | WO | disclosed |