Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13953371 | 1.00 | HSD11B1 (0.59) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL10137094 | 0.91 | HSD11B1 (0.58) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL595384 | 0.91 | HSD11B1 (0.72) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL10137078 | 0.91 | HSD11B1 (0.58) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117180 | 0.91 | HSD11B1 (0.72) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL118735 | 0.91 | HSD11B1 (0.72) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL117181 | 0.91 | HSD11B1 (0.72) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL1755327 | 0.91 | HSD11B1 (0.60) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL115517 | 0.86 | HSD11B1 (0.58) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL115516 | 0.86 | HSD11B1 (0.58) | HSD11B1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183228-B1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2014-08-20 | — | — | EP | disclosed |
| EP-2183229-B1 | SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS INC (US) | 2012-04-18 | — | — | EP | disclosed |