Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17551405 | 0.86 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17551269 | 0.83 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17551304 | 0.82 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17551287 | 0.82 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17551060 | 0.81 | GRM2 (1.00) | GRM2 | |
| SCHEMBL22211168 | 0.81 | GRM2 (0.68) | GRM2 | |
| SCHEMBL17551395 | 0.80 | GRM2 (1.00) | GRM2 | |
| SCHEMBL22211226 | 0.80 | GRM2 (0.72) | GRM2 | |
| SCHEMBL17551272 | 0.79 | GRM2 (1.00) | GRM2 | |
| SCHEMBL22211208 | 0.79 | GRM2 (0.66) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016032921-A1 | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2016-03-03 | — | — | WO | disclosed |