Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22211199 | 0.91 | GRM2 (0.64) | GRM2 | |
| SCHEMBL22211167 | 0.89 | GRM2 (0.64) | GRM2 | |
| SCHEMBL22211208 | 0.87 | GRM2 (0.66) | GRM2 | |
| SCHEMBL22211241 | 0.85 | GRM2 (0.63) | GRM2 | |
| SCHEMBL17551281 | 0.81 | GRM2 (0.65) | GRM2 | |
| SCHEMBL17540970 | 0.81 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17541101 | 0.81 | GRM2 (1.00) | GRM2 | |
| SCHEMBL19497581 | 0.81 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17553676 | 0.81 | GRM2 (0.75) | GRM2 | |
| SCHEMBL17551405 | 0.81 | GRM2 (1.00) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185865-B1 | TETRAHYDRONAPTHTYRIDINE DERIVATIVES AS MGLUR2 NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE. | MERCK SHARP & DOHME (US) | 2020-07-15 | — | — | EP | disclosed |