SCHEMBL1755445

SCHEMBL1755445

Clc1nc(-c2cccc(-c3ccc4ccccc4c3)c2)c2ccccc2n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.57
ALDH1A1 P00352 3/20 0.57
LMNA P02545 3/20 0.49
MAPT P10636 2/20 0.49
ADORA2A P29274 6/20 0.44
KMT2A Q03164 3/20 0.44
OPRK1 P41145 1/20 0.44
HSD17B1 P14061 1/20 0.42
HSD17B2 P37059 1/20 0.42
ADORA1 P30542 2/20 0.42
NUDT1 P36639 1/20 0.41
GLA P06280 1/20 0.41
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CYP17A1 P05093 1/20 0.41
CYP19A1 P11511 1/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
MEN1 O00255 2/20 0.40
ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18646163 0.95 KDM4E (0.62) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL29432929 0.94 KDM4E (0.64) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL15860223 0.94 KDM4E (0.64) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL15860254 0.92 KDM4E (0.62) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL15860259 0.91 KDM4E (0.60) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL30716818 0.91 KDM4E (0.65) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL12683317 0.91 KDM4E (0.65) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL16475867 0.91 KDM4E (0.64) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL15538738 0.89 KDM4E (0.61) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL21174598 0.88 ALDH1A1 (0.50) KDM4EALDH1A1LMNAMAPTADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012050347-A1 NOVEL COMPOUNDS FOR ORGANIC ELECTRONIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2012-04-19 WO disclosed