Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 13/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17555343 | 0.93 | MTOR (0.71) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4438499 | 0.86 | MTOR (0.65) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4437617 | 0.85 | MTOR (0.64) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4554168 | 0.85 | PIK3CA (0.61) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4438164 | 0.85 | PIK3CA (0.67) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4445535 | 0.85 | MTOR (0.71) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4436351 | 0.84 | PIK3CA (0.68) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4441280 | 0.84 | MTOR (0.62) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4446923 | 0.83 | MTOR (0.86) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4443689 | 0.83 | MTOR (0.74) | MTORPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-B1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2016-03-09 | — | — | EP | claimed |