Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.61 |
| ▸ | MTOR | P42345 | 10/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440759 | 0.88 | PIK3CA (0.67) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL4436351 | 0.87 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL4441251 | 0.86 | PIK3CA (0.67) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL4438499 | 0.86 | MTOR (0.65) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL17555331 | 0.85 | MTOR (0.61) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL27943046 | 0.85 | PIK3CA (0.65) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL4555883 | 0.85 | PIK3CA (0.65) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL4439631 | 0.85 | PIK3CA (0.77) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL17571365 | 0.83 | PIK3CA (0.63) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL4436679 | 0.83 | PIK3CA (0.87) | PIK3CAMTORPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |