Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.48 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211495 | 0.83 | PIK3CA (0.45) | PIK3CAPIK3CDMTORCYP1A2GPR119 | |
| SCHEMBL8099679 | 0.83 | PIK3CD (0.52) | PIK3CAPIK3CDMTORJAK1KDM4E | |
| SCHEMBL11925365 | 0.81 | CYP1A2 (0.49) | PIK3CAPIK3CDMTORCYP1A2GPR119 | |
| SCHEMBL8205211 | 0.79 | PIK3CA (0.49) | PIK3CAPIK3CDMTORCYP1A2GPR119 | |
| SCHEMBL8219095 | 0.79 | PIK3CA (0.50) | PIK3CAPIK3CDMTORCYP1A2GPR119 | |
| SCHEMBL11926810 | 0.77 | PIK3CA (0.49) | PIK3CAPIK3CDMTORCYP1A2GPR119 | |
| SCHEMBL11926789 | 0.77 | MTOR (0.47) | PIK3CAPIK3CDMTORCYP1A2GPR119 | |
| SCHEMBL11925449 | 0.75 | CYP1A2 (0.40) | PIK3CAPIK3CDMTORCYP1A2GPR119 | |
| SCHEMBL11926167 | 0.75 | CYP1A2 (0.47) | PIK3CAMTORCYP1A2GPR119PTGS2 | |
| SCHEMBL737784 | 0.72 | PIK3CA (0.83) | PIK3CAPIK3CDMTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176238-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2012-04-18 | — | — | EP | disclosed |