Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.52 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214218 | 0.88 | PIK3CA (0.66) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8093668 | 0.88 | POLB (0.46) | PIK3CDPIK3CAMTORKDM4EMAPT | |
| SCHEMBL1755648 | 0.87 | PIK3CA (0.55) | PIK3CDPIK3CAMTORKDM4EMAPT | |
| SCHEMBL8086866 | 0.85 | MAPT (0.44) | PIK3CDPIK3CAMTORKDM4EMAPT | |
| SCHEMBL1755652 | 0.83 | PIK3CA (0.48) | PIK3CDPIK3CAMTORKDM4EMAPT | |
| SCHEMBL8101524 | 0.83 | MEN1 (0.54) | PIK3CDPIK3CAMTORKDM4EMAPT | |
| SCHEMBL11925797 | 0.82 | PIK3CA (0.49) | PIK3CDPIK3CAMTORKDM4EMAPT | |
| SCHEMBL8215121 | 0.81 | PIK3CA (0.56) | PIK3CDPIK3CAMTORMAPTRAB9A | |
| SCHEMBL8101525 | 0.81 | TP53 (0.51) | PIK3CDPIK3CAMTORKDM4EMAPT | |
| SCHEMBL8093349 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3CAMTORKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |