Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 8/20 | 0.48 |
| ▸ | SLC26A3 | P40879 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8265734 | 0.90 | MAPT (0.62) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL481051 | 0.88 | MRGPRX4 (0.50) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL481089 | 0.87 | GRM2 (0.46) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL1755710 | 0.82 | SMN1; SMN2 (0.36) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL1755729 | 0.81 | GRM2 (0.39) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL481253 | 0.81 | MAPT (0.48) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL1755711 | 0.81 | MAPT (0.43) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL13452568 | 0.80 | GRM2 (0.49) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL13452878 | 0.80 | GRM2 (0.54) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL16242903 | 0.79 | MAPT (0.75) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441762-A1 | Potentiators of Glutamate Receptors | Eli Lilly and Company (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |