Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264747 | 0.95 | GRM2 (0.37) | GRM2MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL10247349 | 0.92 | MAPT (0.47) | GRM2MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL481462 | 0.89 | HTR6 (0.39) | GRM2MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1755705 | 0.86 | PTGER4 (0.38) | — | |
| SCHEMBL481416 | 0.85 | PTGER4 (0.39) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL480816 | 0.85 | HTR6 (0.36) | GRM2MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1755708 | 0.84 | GRM2 (0.39) | GRM2MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL481096 | 0.84 | GRM2 (0.36) | GRM2MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1755706 | 0.83 | CYSLTR1 (0.46) | GRM2MAPT | |
| SCHEMBL480993 | 0.81 | MAPT (0.46) | GRM2MAPTCYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441762-A1 | Potentiators of Glutamate Receptors | Eli Lilly and Company (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |