Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.81 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.46 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL896699 | 0.89 | ALK (1.00) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL1755820 | 0.87 | ALK (0.62) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL897788 | 0.87 | ALK (0.77) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL7814834 | 0.85 | ALK (0.59) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL7806556 | 0.85 | ALK (0.59) | ALK | |
| SCHEMBL7809076 | 0.82 | ALK (0.55) | ALK | |
| SCHEMBL1755760 | 0.82 | ALK (0.85) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL1755809 | 0.81 | ALK (0.54) | ALK | |
| SCHEMBL7809425 | 0.81 | ALK (0.59) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL7811020 | 0.80 | ALK (0.62) | ALKSRPK2SRPK1EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |