Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.62 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.47 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.47 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755769 | 0.87 | ALK (0.81) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL897310 | 0.86 | ALK (0.64) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL1755763 | 0.84 | ALK (0.47) | ALK | |
| SCHEMBL1755782 | 0.82 | ALK (0.49) | ALKSRPK2SRPK1 | |
| SCHEMBL7814687 | 0.80 | ALK (0.46) | ALKSRPK2SRPK1 | |
| SCHEMBL1755894 | 0.80 | ALK (0.57) | ALKSRPK2SRPK1 | |
| SCHEMBL7806140 | 0.79 | ALK (0.52) | ALK | |
| SCHEMBL897264 | 0.79 | ALK (0.70) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL1755875 | 0.78 | ALK (0.52) | ALK | |
| SCHEMBL7812610 | 0.77 | SRPK1 (0.52) | ALKSRPK2SRPK1EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |