Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897184 | 0.80 | ALK (0.63) | ALKKDRKITINSRABL1 | |
| SCHEMBL898048 | 0.77 | ALK (0.86) | ALKKDRKITINSRABL1 | |
| SCHEMBL897391 | 0.77 | ALK (0.66) | ALKKDRKITINSRABL1 | |
| SCHEMBL1755886 | 0.71 | ALK (0.46) | ALKKDR | |
| SCHEMBL20004689 | 0.70 | ALK (0.54) | ALKKDRKITINSRABL1 | |
| SCHEMBL897400 | 0.70 | ALK (1.00) | ALKKDRKIT | |
| SCHEMBL20366678 | 0.70 | ALK (0.55) | ALKKDRINSR | |
| SCHEMBL1755772 | 0.69 | ALK (0.52) | ALKKDR | |
| SCHEMBL7806330 | 0.69 | ALK (0.49) | ALKKDRKITINSRABL1 | |
| SCHEMBL21613407 | 0.69 | ALK (0.60) | ALKKDRKITINSRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |