Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898048 | 0.75 | ALK (0.86) | ALKINSRKDRKITABL1 | |
| SCHEMBL897391 | 0.73 | ALK (0.66) | ALKINSRKDRKITABL1 | |
| SCHEMBL897184 | 0.71 | ALK (0.63) | ALKINSRKDRKITABL1 | |
| SCHEMBL20004720 | 0.70 | ALK (0.53) | ALKINSRKDRGAKACOX3 | |
| SCHEMBL896410 | 0.70 | ALK (1.00) | ALKINSRKDRKITGAK | |
| SCHEMBL1755822 | 0.70 | ALK (0.54) | ALKINSRKDRKITABL1 | |
| SCHEMBL897821 | 0.70 | ALK (0.73) | ALKINSRKDRGAKACOX3 | |
| Hydrochloric Acid SCHEMBL14990818 | 0.70 | ALK (0.98) | ALKINSRKDRKITGAK | |
| Hydrochloric Acid SCHEMBL30730874 | 0.70 | ALK (0.98) | ALKINSRKDRKITGAK | |
| SCHEMBL897758 | 0.69 | ALK (0.80) | ALKINSRKDRKITABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |