Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 18/20 | 0.60 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.59 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20435872 | 0.76 | HPGD (0.55) | NPBWR1 | |
| SCHEMBL17558288 | 0.75 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL20861392 | 0.75 | MGAT2 (0.74) | DGAT2MGAT2 | |
| SCHEMBL17571771 | 0.75 | MGAT2 (1.00) | DGAT2MGAT2 | |
| SCHEMBL20861290 | 0.74 | MGAT2 (0.68) | DGAT2MGAT2 | |
| SCHEMBL17558244 | 0.74 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL17558218 | 0.73 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL19376322 | 0.72 | MGAT2 (0.60) | DGAT2MGAT2 | |
| SCHEMBL19397251 | 0.72 | DGAT2 (0.75) | DGAT2 | |
| SCHEMBL19376218 | 0.71 | DGAT2 (0.76) | DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188731-A1 | ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | Merck Sharp & Dohme Corp. (US) | 2017-07-12 | — | — | EP | claimed |
| WO-2016036638-A1 | ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2016-03-10 | — | — | WO | claimed |