Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 9/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17558396 | 0.90 | POLB (0.39) | POLBL3MBTL1PDE2ANPBWR1MCHR1 | |
| SCHEMBL6174008 | 0.81 | POLB (0.41) | POLBL3MBTL1PDE2ANPBWR1MCHR1 | |
| SCHEMBL6175359 | 0.81 | POLB (0.38) | POLBL3MBTL1PDE2ANPBWR1MCHR1 | |
| SCHEMBL6173212 | 0.81 | ADRB3 (0.40) | POLBL3MBTL1PDE2ANPBWR1MCHR1 | |
| SCHEMBL6171486 | 0.79 | POLB (0.39) | POLBL3MBTL1PDE2ANPBWR1MCHR1 | |
| SCHEMBL6171179 | 0.79 | POLB (0.37) | POLBL3MBTL1PDE2ANPBWR1MCHR1 | |
| SCHEMBL6174854 | 0.78 | POLB (0.36) | POLBL3MBTL1PDE2ALIPECYP2C9 | |
| SCHEMBL6174616 | 0.78 | IGF1R (0.40) | POLBL3MBTL1PDE2ALIPECYP2C9 | |
| SCHEMBL6173023 | 0.78 | IGF1R (0.38) | POLBL3MBTL1PDE2ACYP2C9CYP2C19 | |
| SCHEMBL6205762 | 0.78 | POLB (0.36) | POLBL3MBTL1PDE2ANPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |