Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 5/20 | 0.38 |
| ▸ | PDE2A | O00408 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.33 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.33 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.33 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.33 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.33 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.33 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174008 | 0.90 | POLB (0.41) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL17558336 | 0.90 | POLB (0.43) | POLBL3MBTL1PDE2ACYP3A4CYP2C9 | |
| SCHEMBL6173212 | 0.89 | ADRB3 (0.40) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL6175359 | 0.89 | POLB (0.38) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL6171486 | 0.87 | POLB (0.39) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL6171179 | 0.87 | POLB (0.37) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL6174616 | 0.86 | IGF1R (0.40) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL6173023 | 0.86 | IGF1R (0.38) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL4849527 | 0.86 | PDE2A (0.37) | POLBL3MBTL1ARPDE2ACYP3A4 | |
| SCHEMBL6172626 | 0.86 | IGF1R (0.40) | POLBL3MBTL1ARPDE2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |