Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17558381 | 0.86 | IGF1R (0.34) | IGF1RSMN1; SMN2 | |
| SCHEMBL17558420 | 0.74 | IGF1R (0.37) | IGF1R | |
| SCHEMBL17558364 | 0.74 | IGF1R (0.40) | IGF1R | |
| SCHEMBL17558351 | 0.73 | IGF1R (0.42) | IGF1R | |
| SCHEMBL3727095 | 0.73 | IGF1R (0.34) | IGF1RNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3726823 | 0.72 | IGF1R (0.51) | IGF1RSMN1; SMN2 | |
| SCHEMBL17558348 | 0.71 | TACR1 (0.30) | — | |
| SCHEMBL3727827 | 0.68 | IGF1R (0.40) | IGF1RSMN1; SMN2 | |
| SCHEMBL3728745 | 0.68 | IGF1R (0.40) | IGF1RSMN1; SMN2 | |
| SCHEMBL2942834 | 0.68 | IGF1R (0.40) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |