Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.60 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815537 | 0.88 | ALK (0.57) | ALKKDRKITINSR | |
| SCHEMBL896960 | 0.88 | ALK (0.78) | ALKKDRKITINSR | |
| SCHEMBL10272642 | 0.87 | ALK (0.78) | ALKKDRKITINSR | |
| SCHEMBL7806292 | 0.85 | ALK (0.72) | ALKKDRKITINSR | |
| SCHEMBL7819599 | 0.85 | ALK (0.64) | ALKKDRKITINSR | |
| SCHEMBL1755985 | 0.84 | ALK (0.77) | ALKKDRINSR | |
| SCHEMBL1755834 | 0.83 | ALK (0.65) | ALKKDRKIT | |
| SCHEMBL7806738 | 0.83 | ALK (0.74) | ALKKDRKITINSR | |
| SCHEMBL1755898 | 0.82 | ALK (0.74) | ALKKDRINSR | |
| SCHEMBL7817121 | 0.82 | ALK (0.63) | ALKKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |