Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17558389 | 0.89 | IGF1R (0.53) | IGF1RAR | |
| SCHEMBL6175196 | 0.85 | IGF1R (0.45) | IGF1RAR | |
| SCHEMBL6175947 | 0.83 | IGF1R (0.46) | IGF1RTSHRKMT2A | |
| SCHEMBL6175683 | 0.82 | IGF1R (0.51) | IGF1RAR | |
| SCHEMBL6174494 | 0.82 | IGF1R (0.42) | IGF1RAR | |
| SCHEMBL6172820 | 0.82 | IGF1R (0.42) | IGF1RAR | |
| SCHEMBL6174968 | 0.82 | ITGB2 (0.39) | IGF1RTSHRKMT2A | |
| SCHEMBL6174595 | 0.82 | IGF1R (0.52) | IGF1RAR | |
| SCHEMBL6173683 | 0.82 | IGF1R (0.52) | IGF1RAR | |
| SCHEMBL6177313 | 0.81 | IGF1R (0.45) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |