Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177118 | 0.92 | IGF1R (0.49) | IGF1R | |
| SCHEMBL6172324 | 0.92 | IGF1R (0.47) | IGF1R | |
| SCHEMBL6174504 | 0.90 | IGF1R (0.48) | IGF1R | |
| SCHEMBL17558370 | 0.89 | IGF1R (0.58) | IGF1R | |
| SCHEMBL6176345 | 0.89 | IGF1R (0.53) | IGF1R | |
| SCHEMBL6173508 | 0.88 | IGF1R (0.56) | IGF1R | |
| SCHEMBL6173230 | 0.88 | IGF1R (0.44) | IGF1RLMNAHTT | |
| SCHEMBL6175972 | 0.88 | IGF1R (0.44) | IGF1RLMNA | |
| SCHEMBL6173078 | 0.88 | IGF1R (0.45) | IGF1R | |
| SCHEMBL6175543 | 0.88 | IGF1R (0.56) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |