Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.40 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CBLB | Q13191 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173230 | 0.94 | IGF1R (0.44) | IGF1RLMNAKCNK2NPC1RAB9A | |
| SCHEMBL6174715 | 0.91 | CYP3A4 (0.45) | IGF1RGAAKCNK2KCNK10NPC1 | |
| SCHEMBL17558385 | 0.88 | IGF1R (0.56) | IGF1RLMNA | |
| SCHEMBL6171207 | 0.88 | IGF1R (0.44) | IGF1RNPC1RAB9ASTIM1ORAI1 | |
| SCHEMBL6172324 | 0.88 | IGF1R (0.47) | IGF1R | |
| SCHEMBL6177118 | 0.88 | IGF1R (0.49) | IGF1R | |
| SCHEMBL6173783 | 0.86 | LMNA (0.44) | IGF1RLMNAGAANPC1RAB9A | |
| SCHEMBL6174504 | 0.85 | IGF1R (0.48) | IGF1R | |
| SCHEMBL17558370 | 0.85 | IGF1R (0.58) | IGF1R | |
| SCHEMBL6176345 | 0.84 | IGF1R (0.53) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |