Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.78 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283422 | 0.91 | ALK (0.82) | ALKKDRKITABL1INSR | |
| SCHEMBL897237 | 0.88 | ALK (1.00) | ALKKDRKITABL1INSR | |
| SCHEMBL897239 | 0.88 | ALK (1.00) | ALKKDRKITABL1INSR | |
| SCHEMBL7812706 | 0.87 | ALK (0.63) | ALKKDRKIT | |
| SCHEMBL1755938 | 0.83 | ALK (0.65) | ALKKDRKIT | |
| SCHEMBL1755857 | 0.83 | ALK (0.64) | ALKKDRKITABL1INSR | |
| SCHEMBL1755795 | 0.82 | ALK (0.66) | ALKKDRKIT | |
| SCHEMBL7805237 | 0.82 | ALK (0.55) | ALKKDRKITABL1INSR | |
| SCHEMBL7809165 | 0.80 | ALK (0.55) | ALKKDRKIT | |
| SCHEMBL7809847 | 0.80 | ALK (0.63) | ALKKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |