Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL896920 | 0.89 | ALK (0.68) | ALKKITKDR | |
| SCHEMBL896919 | 0.89 | ALK (0.68) | ALKKITKDR | |
| SCHEMBL1755929 | 0.87 | ALK (0.59) | ALKKITKDR | |
| SCHEMBL7808984 | 0.83 | ALK (0.65) | ALKKDR | |
| SCHEMBL7807485 | 0.82 | ALK (0.62) | ALK | |
| SCHEMBL1755847 | 0.80 | ALK (0.78) | ALKKITKDR | |
| SCHEMBL7811634 | 0.80 | ALK (0.62) | ALK | |
| SCHEMBL1755797 | 0.79 | ALK (0.62) | ALK | |
| SCHEMBL7805237 | 0.79 | ALK (0.55) | ALKKITKDR | |
| SCHEMBL7800549 | 0.78 | ALK (0.55) | ALKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |