Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755883 | 0.97 | ALK (0.56) | ALKHTR1AHTR6 | |
| SCHEMBL898274 | 0.88 | ALK (0.72) | ALKEML4 | |
| SCHEMBL7801170 | 0.88 | ALK (0.53) | ALKHTR6 | |
| SCHEMBL24676452 | 0.87 | ALK (0.59) | ALK | |
| SCHEMBL897187 | 0.85 | ALK (0.73) | ALK | |
| SCHEMBL7812393 | 0.83 | ALK (0.77) | ALK | |
| SCHEMBL7808626 | 0.83 | ALK (0.66) | ALK | |
| SCHEMBL7809425 | 0.81 | ALK (0.59) | ALKEML4 | |
| SCHEMBL1755990 | 0.80 | ALK (0.55) | ALK | |
| SCHEMBL7811873 | 0.80 | ALK (0.72) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |