SCHEMBL7801170

SCHEMBL7801170

CC(C)Oc1cc2c(cc1C1=CCNCC1)C(=O)c1c([nH]c3cc(N)ccc13)C2(C)C

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 19/20 0.53
HTR6 P50406 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1755883 0.90 ALK (0.56) ALKHTR6
SCHEMBL897624 0.88 ALK (0.70) ALK
SCHEMBL1755848 0.88 ALK (0.55) ALKHTR6
SCHEMBL17448463 0.87 ALK (0.51) ALKHTR6
SCHEMBL7808626 0.82 ALK (0.66) ALK
SCHEMBL7812393 0.82 ALK (0.77) ALK
SCHEMBL1755884 0.81 ALK (0.55) ALK
SCHEMBL24676452 0.80 ALK (0.59) ALK
SCHEMBL7806330 0.80 ALK (0.49) ALK
SCHEMBL1755890 0.79 ALK (0.49) ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010143664-A1 TETRACYCLIC COMPOUND 中外製薬株式会社 (JP) 2010-12-16 WO disclosed