SCHEMBL17559554

SCHEMBL17559554

CC(C)(Br)C(=O)c1ccc2c(c1)Sc1cc(C(=O)C(C)(C)Br)ccc1O2

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
LMNA P02545 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
MAPT P10636 2/20 0.35
CTNNB1 P35222 1/20 0.32
NOX1 Q9Y5S8 2/20 0.32
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
ALOX5 P09917 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19253139 0.87 NPC1 (0.37) NPC1RAB9ALMNAL3MBTL1MAPT
SCHEMBL19253126 0.83 NPC1 (0.35) NPC1RAB9ALMNAL3MBTL1MAPT
SCHEMBL17559563 0.82 NOX1 (0.38) LMNAL3MBTL1MAPTNOX1MAPK1
SCHEMBL5358787 0.79 MAPT (0.46) NPC1RAB9ALMNAL3MBTL1MAPT
SCHEMBL17559556 0.77 NPC1 (0.40) NPC1RAB9AMAPTCTNNB1TDP1
SCHEMBL17559560 0.75 PTGS1 (0.34) CTNNB1ALOX5
SCHEMBL17559571 0.75 GAA (0.49) NPC1RAB9ALMNAL3MBTL1MAPT
SCHEMBL9778273 0.74 NOX1 (0.40) NPC1RAB9ALMNAL3MBTL1MAPT
SCHEMBL19268227 0.72 NPC1 (0.32) NPC1RAB9ALMNAL3MBTL1MAPT
SCHEMBL14468403 0.72 CYP2A6 (0.49) NPC1RAB9ALMNAL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3189083-B2 POLYCYCLIC PHOTOINITIATORS IGM GROUP B V (NL) 2023-07-05 EP disclosed
EP-3189083-B2 POLYCYCLIC PHOTOINITIATORS IGM GROUP B V (NL) 2023-07-05 EP disclosed
EP-3189083-B1 POLYCYCLIC PHOTOINITIATORS IGM GROUP B V (NL) 2020-04-08 EP disclosed
CN-107075000-B Polycyclic photoinitiators IGM集团公司 2020-01-31 CN disclosed
US-10113075-B2 Polycyclic photoinitiators IGM MALTA LIMITED (MT) 2018-10-30 US disclosed
US-20170240755-A1 POLYCYCLIC PHOTOINITIATORS IGM GROUP B.V. (NL) 2017-08-24 US disclosed
US-20170240755-A1 POLYCYCLIC PHOTOINITIATORS IGM GROUP B.V. (NL) 2017-08-24 US disclosed
US-20170240755-A1 POLYCYCLIC PHOTOINITIATORS IGM GROUP B.V. (NL) 2017-08-24 US disclosed
EP-3189083-A1 POLYCYCLIC PHOTOINITIATORS IGM Malta Limited (MT) 2017-07-12 EP disclosed
WO-2016034963-A1 POLYCYCLIC PHOTOINITIATORS BASF SE (DE) 2016-03-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170240755-A1 POLYCYCLIC PHOTOINITIATORS C1R, C9, C5 NPC1 3719/4885RAB9A 1172/4885LMNA 2538/4885
US-10113075-B2 Polycyclic photoinitiators C1R, C9, C5 NPC1 3723/4885RAB9A 1190/4885LMNA 2550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.