Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17554451 | 0.85 | MAOB (0.54) | MAOBKDM4AMMP2MMP9 | |
| SCHEMBL17560097 | 0.81 | GLA (0.42) | MAOBRAB9AKDM4E | |
| SCHEMBL17560027 | 0.80 | MAOB (0.55) | MAOBKDM4AMMP2MMP9CA12 | |
| SCHEMBL17560123 | 0.80 | MAOB (0.57) | MAOBKDM4AMMP2MMP9CA12 | |
| SCHEMBL796697 | 0.78 | MEN1 (0.49) | ALDH1A1MEN1KMT2A | |
| SCHEMBL17554392 | 0.78 | MAOB (0.41) | MAOBMMP2MMP9ALDH1A1HTT | |
| SCHEMBL17560013 | 0.78 | MAOB (0.41) | MAOBMMP2MMP9ALDH1A1HTT | |
| SCHEMBL17560010 | 0.78 | MAOB (0.41) | MAOBMMP2MMP9ALDH1A1HTT | |
| SCHEMBL17554393 | 0.78 | MAOB (0.41) | MAOBMMP2MMP9ALDH1A1HTT | |
| SCHEMBL3125878 | 0.77 | MAOB (0.68) | MAOBKDM4ACA12CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189059-A2 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016034946-A2 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-03-10 | — | — | WO | disclosed |