Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14411662 | 0.85 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL28232379 | 0.85 | MAPT (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3SLC18A2 | |
| SCHEMBL3561676 | 0.84 | USP2 (0.42) | PDE4BUSP2MAPT | |
| SCHEMBL4822309 | 0.84 | USP2 (0.42) | PDE4BUSP2MAPT | |
| SCHEMBL18129961 | 0.84 | USP2 (0.42) | PDE4BUSP2MAPT | |
| Hydrochloric Acid SCHEMBL28060471 | 0.83 | MAPT (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3SLC18A2 | |
| SCHEMBL4951081 | 0.82 | GAA (0.37) | SCN9APDE4BGAASLC18A2MAPT | |
| SCHEMBL22220324 | 0.82 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL15432263 | 0.81 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3SCN9A | |
| SCHEMBL7397131 | 0.80 | SCN9A (0.34) | CHRNB2CHRNA4CHRNA3SCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016034134-A1 | HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-03-10 | — | — | WO | disclosed |