Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2505924 | 0.88 | NPC1 (0.40) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL28499108 | 0.88 | BCHE (0.40) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL4261396 | 0.88 | NPC1 (0.40) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL28914333 | 0.87 | NPC1 (0.39) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL28410806 | 0.87 | NPC1 (0.39) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL30336274 | 0.85 | NPC1 (0.38) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL28716091 | 0.84 | NPC1 (0.40) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL28719208 | 0.82 | NPC1 (0.40) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL30262558 | 0.81 | NPC1 (0.40) | NPC1RAB9ABCHEMAPTLMNA | |
| SCHEMBL20775430 | 0.79 | MAPT (0.42) | NPC1RAB9ABCHEMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016035006-A1 | NOVEL NUCLEOTIDE ANALOGS, PROCESS FOR THE PREPARATION OF SOFOSBUVIR AND ITS ANALOGS, NOVEL FORMS OF SOFOSBUVIR AND SOLID DISPERSION OF SOFOSBUVIR | DR. REDDY’S LABORATORIES LIMITED (IN) | 2016-03-10 | — | — | WO | disclosed |