Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10074944 | 0.88 | PKM (0.52) | PKMMEN1KMT2AMAPTTHRB | |
| SCHEMBL10074947 | 0.85 | BRD4 (0.56) | PKMMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL10074946 | 0.83 | PKM (0.50) | PKMMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL10075479 | 0.74 | PKM (0.34) | PKMKMT2AHTT | |
| SCHEMBL17174222 | 0.71 | CES1 (0.66) | PKMMEN1KMT2AMAPTTDP1 | |
| SCHEMBL10074948 | 0.71 | PKM (0.54) | PKMMEN1KMT2AMAPTTDP1 | |
| SCHEMBL12903989 | 0.70 | MAPT (0.66) | PKMMEN1KMT2AMAPTTDP1 | |
| SCHEMBL23093601 | 0.69 | PKM (0.61) | PKMMEN1KMT2AMAPTTDP1 | |
| SCHEMBL2594417 | 0.69 | PKM (0.69) | PKMMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8976245 | 0.69 | PKM (0.67) | PKMMEN1KMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655350-B1 | BICYCLIC PKM2 ACTIVATORS | AGIOS PHARMACEUTICALS INC (US) | 2016-03-09 | — | — | EP | disclosed |