Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13475757 | 0.88 | KMT2A (0.36) | KMT2AMEN1ALDH1A1KDM4EADAMTS5 | |
| SCHEMBL10305542 | 0.87 | KMT2A (0.37) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL7533087 | 0.83 | KMT2A (0.40) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL7527644 | 0.80 | POLB (0.46) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL7524362 | 0.78 | POLB (0.38) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL7536559 | 0.78 | KMT2A (0.42) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL7536976 | 0.77 | KMT2A (0.38) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10305569 | 0.77 | KMT2A (0.36) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL17551655 | 0.76 | KMT2A (0.39) | KMT2AMEN1CACNA1GCACNA1HALDH1A1 | |
| SCHEMBL7542200 | 0.74 | POLB (0.49) | KMT2AALDH1A1ADAMTS5LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2153832-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |