Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8232179 | 0.92 | ADAM17 (0.73) | ADAM17 | |
| SCHEMBL17570797 | 0.85 | ADAM17 (0.66) | ADAM17 | |
| SCHEMBL17570599 | 0.85 | ADAM17 (0.85) | ADAM17 | |
| SCHEMBL17570676 | 0.83 | ADAM17 (0.69) | ADAM17 | |
| SCHEMBL17570724 | 0.83 | ADAM17 (0.56) | ADAM17 | |
| SCHEMBL8232816 | 0.82 | ADAM17 (0.80) | ADAM17 | |
| SCHEMBL13436422 | 0.82 | ADAM17 (0.80) | ADAM17 | |
| SCHEMBL17570687 | 0.82 | ADAM17 (0.72) | ADAM17 | |
| SCHEMBL12860555 | 0.81 | ADAM17 (0.76) | ADAM17 | |
| SCHEMBL8232171 | 0.81 | ADAM17 (0.81) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976849-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |