Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8227297 | 0.89 | ADAM17 (0.67) | ADAM17 | |
| SCHEMBL8420474 | 0.88 | ADAM17 (0.58) | ADAM17 | |
| SCHEMBL8227936 | 0.86 | ADAM17 (0.60) | ADAM17 | |
| SCHEMBL8227022 | 0.85 | ADAM17 (0.55) | ADAM17 | |
| SCHEMBL14466298 | 0.79 | ADAM17 (0.65) | ADAM17 | |
| SCHEMBL7906085 | 0.79 | ADAM17 (0.78) | ADAM17 | |
| SCHEMBL13921897 | 0.79 | ADAM17 (0.79) | ADAM17 | |
| SCHEMBL8232280 | 0.78 | ADAM17 (0.65) | ADAM17 | |
| SCHEMBL8232596 | 0.78 | ADAM17 (0.69) | ADAM17 | |
| SCHEMBL8232363 | 0.77 | ADAM17 (0.77) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976849-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |