Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.72 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.64 |
| ▸ | MMP1 | P03956 | 1/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.64 |
| ▸ | MMP14 | P50281 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899524 | 0.91 | ADAM17 (0.78) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL14466298 | 0.89 | ADAM17 (0.65) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL7899477 | 0.89 | ADAM17 (0.86) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL8227461 | 0.87 | ADAM17 (0.75) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL7897522 | 0.86 | ADAM17 (0.82) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL7897431 | 0.86 | ADAM17 (0.81) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL5956272 | 0.86 | ADAM17 (0.81) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL7903343 | 0.86 | ADAM17 (0.84) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL7905361 | 0.86 | ADAM17 (0.84) | ADAM17ADAM10MMP1MMP2MMP14 | |
| SCHEMBL7900271 | 0.86 | ADAM17 (0.84) | ADAM17ADAM10MMP1MMP2MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976849-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |