Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 7/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17570736 | 0.80 | TNF (0.48) | TNFADAM17NPC1ALDH1A1POLB | |
| SCHEMBL8233318 | 0.73 | ADAM17 (0.53) | TNFADAM17 | |
| SCHEMBL8422250 | 0.68 | TNF (0.45) | TNFADAM17NPC1ALDH1A1POLB | |
| SCHEMBL12860730 | 0.66 | ADAM17 (0.75) | ADAM17 | |
| SCHEMBL8232609 | 0.66 | ADAM17 (0.75) | ADAM17 | |
| SCHEMBL8227241 | 0.66 | ADAM17 (0.77) | ADAM17 | |
| SCHEMBL8227781 | 0.66 | ADAM17 (0.77) | ADAM17 | |
| SCHEMBL18699826 | 0.65 | ADAM17 (0.43) | TNFADAM17 | |
| SCHEMBL12862733 | 0.65 | ADAM17 (0.49) | TNFADAM17 | |
| SCHEMBL13362709 | 0.63 | TNF (0.51) | TNFADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976849-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |