Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17573364 | 0.83 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL30749598 | 0.82 | LRRK2 (0.51) | LRRK2ALDH1A1LMNA | |
| SCHEMBL27170833 | 0.82 | LRRK2 (0.51) | LRRK2ALDH1A1LMNA | |
| SCHEMBL25142292 | 0.82 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL17559203 | 0.81 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL17573381 | 0.81 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL23125421 | 0.81 | LRRK2 (0.63) | LRRK2ALDH1A1LMNA | |
| SCHEMBL17573299 | 0.81 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL17573366 | 0.80 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL25142074 | 0.80 | LRRK2 (0.61) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954240-B2 | Compounds inhibiting leucine-rich repeat kinase enzyme activity | MERCK SHARP & DOHME CORP. (US) | 2021-03-23 | — | — | US | disclosed |
| WO-2016036586-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10954240-B2 | Compounds inhibiting leucine-rich repeat kinase enzyme activity | LRRK2, LRRC59, LRRC47 | LRRK2 1/4885ALDH1A1 4051/4885LMNA 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.