Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757634 | 0.90 | KMT2A (0.45) | KMT2AKDM4EALDH1A1HSD17B10TDP1 | |
| SCHEMBL1757829 | 0.87 | PTGDR2 (0.52) | ALDH1A1HSD17B10PTGDR2 | |
| SCHEMBL1757944 | 0.77 | PTGDR2 (0.56) | ALDH1A1HSD17B10PTGDR2 | |
| SCHEMBL1758033 | 0.74 | KDM4E (0.46) | KMT2AKDM4EALDH1A1HSD17B10TDP1 | |
| SCHEMBL11606942 | 0.73 | KDM4E (0.55) | KMT2AKDM4EALDH1A1HSD17B10TDP1 | |
| SCHEMBL1757545 | 0.72 | KMT2A (0.47) | KMT2AKDM4EALDH1A1HSD17B10TDP1 | |
| SCHEMBL11232387 | 0.70 | PTGDR2 (0.58) | KMT2AKDM4EALDH1A1HSD17B10TDP1 | |
| SCHEMBL11605995 | 0.69 | KDM4E (0.59) | KMT2AKDM4EALDH1A1HSD17B10TDP1 | |
| SCHEMBL1757727 | 0.69 | PTGDR2 (0.81) | PTGDR2 | |
| SCHEMBL1758092 | 0.69 | PTGDR2 (0.49) | KMT2AKDM4ETDP1MEN1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | WYETH, LLC (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | HRH2, CRHR2, CRHR1 | KMT2A 3787/4885KDM4E 4693/4885ALDH1A1 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.