Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CRHBP | P24387 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CTSE | P14091 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18692161 | 0.87 | KDM4E (0.40) | KDM4EMAPTTHRBHTTHPGD | |
| SCHEMBL17045555 | 0.85 | PIK3CA (0.42) | KDM4EMAPTTHRBHTTGPR119 | |
| SCHEMBL17580620 | 0.82 | KDM4E (0.43) | KDM4EMAPTTHRBHTTMEN1 | |
| SCHEMBL15283360 | 0.81 | KDM4E (0.51) | KDM4EMAPTTHRBHTTMEN1 | |
| SCHEMBL22505654 | 0.80 | KDM4E (0.47) | KDM4EMAPTTHRBGPR119CTSD | |
| SCHEMBL24007611 | 0.78 | STS (0.49) | KDM4EMAPTTHRBGPR119CTSD | |
| SCHEMBL13974673 | 0.78 | TP53 (0.57) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL4477598 | 0.77 | KDM4E (0.52) | KDM4EMAPTTHRBHTTMEN1 | |
| SCHEMBL12614693 | 0.77 | GPR119 (0.56) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL6783179 | 0.77 | KDM4E (0.40) | KDM4EMAPTTHRBHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |