Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 10/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17580664 | 0.95 | HTR6 (0.45) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580797 | 0.90 | HTR2A (0.48) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3750029 | 0.89 | HTR6 (0.47) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3644576 | 0.86 | HTR6 (0.46) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580937 | 0.85 | HTR2A (0.47) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580776 | 0.84 | HTR2A (0.44) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580842 | 0.83 | HTR6 (0.53) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL19327016 | 0.83 | HTR6 (0.51) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3645947 | 0.82 | HTR6 (0.52) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580611 | 0.81 | HTR2A (0.48) | HTR6HTR2AHTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185555-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBVIE DEUTSCHLAND (DE) | 2016-03-16 | — | — | EP | claimed |