Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 19/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12803022 | 0.91 | CHRM1 (0.55) | CHRM1PDE2APDE11A | |
| SCHEMBL17585466 | 0.89 | CHRM1 (0.60) | CHRM1PDE2APDE11A | |
| SCHEMBL17585465 | 0.88 | CHRM1 (0.48) | CHRM1PDE2APDE11A | |
| SCHEMBL17585467 | 0.87 | CHRM1 (0.49) | CHRM1PDE2APDE11A | |
| SCHEMBL17656783 | 0.81 | CHRM1 (0.48) | CHRM1 | |
| SCHEMBL2222661 | 0.80 | CHRM1 (0.57) | CHRM1PDE2APDE11A | |
| SCHEMBL2225587 | 0.80 | CHRM1 (0.57) | CHRM1PDE2APDE11A | |
| SCHEMBL6889615 | 0.80 | CHRM1 (0.55) | CHRM1PDE2APDE11A | |
| SCHEMBL2224239 | 0.80 | CHRM1 (0.56) | CHRM1PDE2APDE11A | |
| SCHEMBL2223555 | 0.80 | CHRM1 (0.69) | CHRM1PDE2APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160075656-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075656-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRL1, CHRM2 | CHRM1 1/4885PDE2A 1258/4885PDE11A 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.