Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892942 | 0.90 | CHRM1 (0.49) | CHRM1BRD4CNR2GSK3BKCNH2 | |
| SCHEMBL12803022 | 0.89 | CHRM1 (0.55) | CHRM1 | |
| SCHEMBL6890674 | 0.87 | CHRM1 (0.49) | CHRM1BRD4KCNH2NPC1RAB9A | |
| SCHEMBL12802494 | 0.85 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL12802497 | 0.85 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL17585463 | 0.81 | CHRM1 (0.48) | CHRM1 | |
| SCHEMBL2223239 | 0.78 | P2RX7 (0.33) | CHRM1P2RX7 | |
| SCHEMBL2222661 | 0.78 | CHRM1 (0.57) | CHRM1 | |
| SCHEMBL2225587 | 0.78 | CHRM1 (0.57) | CHRM1 | |
| SCHEMBL2224239 | 0.77 | CHRM1 (0.56) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |