Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.44 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | FABP6 | P51161 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195848 | 0.86 | SMN1; SMN2 (0.67) | ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL17586177 | 0.81 | SLC2A1 (0.73) | ALDH1A1RAB9ASMN1; SMN2KDM4EHTT | |
| SCHEMBL17586156 | 0.75 | IP6K1 (0.41) | SMN1; SMN2SLC2A1IP6K1IP6K3IP6K2 | |
| SCHEMBL17586174 | 0.73 | IP6K1 (0.39) | SMN1; SMN2SLC2A1IP6K1IP6K3IP6K2 | |
| SCHEMBL29406130 | 0.72 | RAB9A (1.00) | ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1801617 | 0.72 | RAB9A (1.00) | ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL17586185 | 0.71 | IP6K1 (0.52) | SMN1; SMN2IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL17586159 | 0.71 | IP6K1 (0.46) | SMN1; SMN2SLC2A1IP6K1IP6K3IP6K2 | |
| SCHEMBL263154 | 0.70 | SLC2A1 (0.74) | SMN1; SMN2SLC2A1IP6K1IP6K3IP6K2 | |
| SCHEMBL28736625 | 0.70 | KDM4E (0.51) | ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493426-B2 | Quinazolinone derivatives useful as FGFR kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | FGFR1, FGFR3, FGFR2 | ALDH1A1 1971/4885HPGD 1333/4885RAB9A 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.