Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31339147 | 0.83 | MTOR (0.48) | SMN1; SMN2KMT2AMTORPIK3CDPIK3CA | |
| SCHEMBL1609125 | 0.83 | MTOR (0.48) | SMN1; SMN2KMT2AMTORPIK3CDPIK3CA | |
| SCHEMBL21740864 | 0.81 | MTOR (0.41) | SMN1; SMN2KMT2AMTORPIK3CDPIK3CA | |
| SCHEMBL1608475 | 0.80 | MTOR (0.56) | MTORPIK3CDPIK3CA | |
| SCHEMBL1608473 | 0.80 | MTOR (0.56) | MTORPIK3CDPIK3CA | |
| SCHEMBL2395003 | 0.80 | TLR7 (0.50) | SMN1; SMN2TLR7MTORPIK3CAPDE10A | |
| SCHEMBL30439903 | 0.80 | TLR7 (0.50) | SMN1; SMN2TLR7MTORPIK3CAPDE10A | |
| SCHEMBL6900338 | 0.80 | MAPT (0.49) | SMN1; SMN2KMT2APIK3CAPDE10AMAPT | |
| SCHEMBL1608915 | 0.79 | MTOR (0.52) | SMN1; SMN2KMT2AMTORPIK3CDPIK3CA | |
| SCHEMBL23287625 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2AMTORPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499143-B1 | N7-SUBSTITUTED PURINE AND PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-03-16 | — | — | EP | disclosed |