Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.30 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.30 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.30 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592600 | 1.00 | ALDH1A1 (0.33) | ALDH1A1DDB1CRBNSMN1; SMN2MAPT | |
| SCHEMBL17592313 | 0.79 | — | — | |
| SCHEMBL17592312 | 0.79 | — | — | |
| SCHEMBL17592658 | 0.77 | DDB1 (0.43) | ALDH1A1DDB1CRBNSMN1; SMN2MAPT | |
| SCHEMBL2790819 | 0.71 | HPGD (0.33) | ALDH1A1LMNAKMT2ANPSR1CYP2C9 | |
| SCHEMBL2790817 | 0.71 | HPGD (0.33) | ALDH1A1LMNAKMT2ANPSR1CYP2C9 | |
| SCHEMBL25046039 | 0.68 | NPC1 (0.39) | ALDH1A1MAPTLMNAMEN1GAA | |
| SCHEMBL26983662 | 0.68 | C5AR1 (0.34) | LMNAKDM4EATMNPSR1TDP1 | |
| SCHEMBL30727025 | 0.68 | C5AR1 (0.34) | LMNAKDM4EATMNPSR1TDP1 | |
| SCHEMBL30727008 | 0.67 | C5AR1 (0.36) | ALDH1A1DDB1CRBNSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200123142-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2020-04-23 | — | — | US | disclosed |
| US-20200123142-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2020-04-23 | — | — | US | disclosed |
| US-10106510-B2 | Substituted isoxazoles for treating cancer | Epizyme, Inc. (US) | 2018-10-23 | — | — | US | disclosed |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2017-12-21 | — | — | US | disclosed |
| EP-3190891-A1 | SUBSTITUTED CYCLOHEXYLAMINE COMPOUNDS | Epizyme, Inc. (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016040502-A1 | SUBSTITUTED CYCLOHEXYLAMINE COMPOUNDS | Epizyme, Inc. (US) | 2016-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123142-A1 | Substituted Cyclohexylamine Compounds | SMYD3, SMYD2, SNRPD3 | ALDH1A1 1867/4885DDB1 818/4885CRBN 1343/4885 |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | SMYD3, SMYD2, SNRPD3 | ALDH1A1 1867/4885DDB1 818/4885CRBN 1343/4885 |
| US-10106510-B2 | Substituted isoxazoles for treating cancer | SMYD3, SMYD2, SNRPD3 | ALDH1A1 858/4885DDB1 1014/4885CRBN 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.