Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592983 | 0.85 | NPC1 (0.35) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17593077 | 0.85 | NPC1 (0.37) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17593251 | 0.80 | L3MBTL1 (0.40) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17592907 | 0.80 | PHGDH (0.43) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17593119 | 0.79 | GRM4 (0.48) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17592998 | 0.79 | PHGDH (0.40) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17592994 | 0.78 | KDM4E (0.40) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17593235 | 0.78 | TP53 (0.52) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17593140 | 0.77 | RXFP1 (0.52) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL17593175 | 0.77 | HPGD (0.40) | NPC1RAB9AHPGDSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |