Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28123448 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBTDP1ALDH1A1MAPT | |
| SCHEMBL596066 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTDP1ALDH1A1HTT | |
| SCHEMBL28013853 | 0.86 | HDAC6 (0.60) | SMN1; SMN2POLBTDP1MARS1HDAC6 | |
| SCHEMBL28014537 | 0.86 | HDAC6 (0.46) | SMN1; SMN2POLBTDP1ALDH1A1RAB9A | |
| SCHEMBL14152218 | 0.84 | PHGDH (0.46) | SMN1; SMN2POLBTDP1ALDH1A1MAPT | |
| SCHEMBL4692309 | 0.84 | PPARG (0.54) | SMN1; SMN2POLBTDP1RAB9AMAPT | |
| SCHEMBL28013857 | 0.84 | MARS1 (0.45) | SMN1; SMN2POLBTDP1ALDH1A1MAPT | |
| SCHEMBL6335193 | 0.84 | SMN1; SMN2 (0.79) | SMN1; SMN2POLBTDP1ALDH1A1HTT | |
| SCHEMBL4678362 | 0.83 | HDAC6 (0.46) | SMN1; SMN2POLBTDP1ALDH1A1MARS1 | |
| SCHEMBL27687138 | 0.83 | SMN1; SMN2 (0.69) | SMN1; SMN2POLBTDP1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |
| CN-1230166-C | Gyrase inhibitors and uses thereof | VERTEX PHARMA (US) | 2005-12-07 | — | — | CN | disclosed |
| CN-1400898-A | Gyrase inhibitors and uses thereof | VERTEX PHARMA (US) | 2003-03-05 | — | — | CN | disclosed |