MARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL117650	1.00	19/20
SCHEMBL116345	1.00	18/20
SCHEMBL116346	1.00	18/20
SCHEMBL116364	1.00	18/20
SCHEMBL117374	1.00	18/20
SCHEMBL117471	1.00	18/20
SCHEMBL117498	1.00	18/20
SCHEMBL117499	1.00	18/20
SCHEMBL117647	1.00	18/20
SCHEMBL117705	1.00	18/20
SCHEMBL116352	1.00	17/20
SCHEMBL117716	1.00	17/20
SCHEMBL118666	1.00	17/20
SCHEMBL117667	0.60	16/20
SCHEMBL117660	1.00	14/20
SCHEMBL118672	1.00	14/20
SCHEMBL116301	1.00	13/20
SCHEMBL116342	1.00	13/20
SCHEMBL117500	1.00	13/20
SCHEMBL1110928	0.53	13/20

Clinical trials — most relevant to MARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.	PHASE1/PHASE2	COMPLETED
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment	PHASE2	COMPLETED
Application of mRNA Immunotherapy Technology in Epstein-Barr Virus-related Refractory Malignant Tumors	PHASE1	ACTIVE_NOT_RECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Dietary Effects of Sulfur Amino Acids	nan	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC	nan	UNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
The Role of Maspin in Colorectal Carcinoma, an Immunohistochemical Study	nan	NOT_YET_RECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Immunophenotyping and Xist Gene in AML	nan	UNKNOWN
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
UW Undiagnosed Genetic Diseases Program	nan	RECRUITING
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Selinexor (Nexpovio®) (SVd) in Patients With Relapsed or Refractory Multiple Myeloma	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a MARS1 binder may also engage these)

Protein	Name	Similarity
Q2T9L8	—	1.000	Q2T9L8 →
Q68FL6	—	1.000	Q68FL6 →
Q6PF21	—	1.000	Q6PF21 →
Q04462	—	0.999	Q04462 →
Q15031	—	0.995	Q15031 →
Q8BYM8	—	0.987	Q8BYM8 →
P49696	—	0.985	P49696 →
MARS2	Methionine--tRNA ligase, mitochondrial	0.985	landscape →
Q5RDP4	—	0.985	Q5RDP4 →
Q60967	—	0.983	Q60967 →
Q4R646	—	0.983	Q4R646 →
Q922E4	—	0.983	Q922E4 →
Q9Y7Y8	—	0.983	Q9Y7Y8 →
Q9ZTS1	—	0.983	Q9ZTS1 →
Q9Z1Q9	—	0.983	Q9Z1Q9 →
VARS1	Valine--tRNA ligase	0.982	landscape →
Q4R550	—	0.982	Q4R550 →
Q5ZKA2	—	0.982	Q5ZKA2 →
COASY	Bifunctional coenzyme A synthase	0.982	landscape →
Q7ZU90	—	0.981	Q7ZU90 →
P28350	—	0.981	P28350 →
Q9SVN5	—	0.981	Q9SVN5 →
Q5RCH4	—	0.981	Q5RCH4 →
Q7QIL2	—	0.981	Q7QIL2 →
A1VKF9	—	0.981	A1VKF9 →
Q08BC6	—	0.981	Q08BC6 →
Q91V92	—	0.981	Q91V92 →
Q9JX22	—	0.981	Q9JX22 →
B3M1E1	—	0.981	B3M1E1 →
Q8VDC0	—	0.981	Q8VDC0 →