Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.92 |
| ▸ | MEN1 | O00255 | 4/20 | 0.92 |
| ▸ | NAMPT | P43490 | 1/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | GPR27 | Q9NS67 | 8/20 | 0.70 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | GBA1 | P04062 | 1/20 | 0.67 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.67 |
| ▸ | FGB | P02675 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12010895 | 0.91 | KMT2A (0.83) | KMT2AMEN1USP2ALDH1A1PKM | |
| SCHEMBL12010897 | 0.90 | KMT2A (0.91) | KMT2AMEN1USP2ALDH1A1PKM | |
| SCHEMBL17066584 | 0.87 | GPR55 (0.80) | KMT2AMEN1NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL12010900 | 0.87 | KMT2A (0.81) | KMT2AMEN1USP2ALDH1A1PKM | |
| SCHEMBL30926705 | 0.86 | KMT2A (0.70) | KMT2AMEN1NAMPTUSP2ALDH1A1 | |
| SCHEMBL27179849 | 0.86 | KMT2A (0.70) | KMT2AMEN1NAMPTUSP2ALDH1A1 | |
| SCHEMBL2561573 | 0.85 | KMT2A (1.00) | KMT2AMEN1USP2ALDH1A1PKM | |
| SCHEMBL27180941 | 0.85 | KMT2A (0.67) | KMT2AMEN1NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27180069 | 0.84 | PPIA (0.73) | KMT2AMEN1NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27181616 | 0.84 | PPIA (0.73) | KMT2AMEN1NAMPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |